Article
Increased frequency of rapid acetylator genotypes in patients with brain astrocytoma and meningioma.
Acta neurologica Scandinavica - 1 May 2006
Olivera M, Martínez C, Molina J A, Alonso-Navarro H, Jiménez-Jiménez F J, García-Martín E, Benítez J, Agúndez J A G
Abstract excerpt
OBJECTIVES: The arylamine N-acetyltransferase (NAT2) is a polymorphic enzyme involved in deactivation and activation of carcinogens through N- and O-acetylation. We investigated the association between the genetic NAT2 polymorphism and brain tumors by analysis of genomic DNA from 71 brain tumor patients and 258 healthy controls. MATERIALS AND METHODS: Seven single nucleotide polymorphisms of the NAT2 gene were...
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