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Article

Genomic response to interferon-α in chimpanzees: Implications of rapid downregulation for hepatitis C kinetics

20 Apr 2006

Abstract excerpt

The mechanism of the interferon-alpha (IFN-alpha)-induced antiviral response during hepatitis C virus (HCV) therapy is n o t completely understood. In this study,we examined the transcriptional response to IFN-alpha in uninfected chimpanzees after single doses of chimpanzee, human, or human-pegylated IFN-alpha. Liver and peripheral blood mononuclear cell (PBMC) samples were used for total genome microarray...

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PMID: 16628626
DOI: 10.1002/hep.21167

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