Article
Fibrin and activated platelets cooperatively guide stem cells to a vascular injury and promote differentiation towards an endothelial cell phenotype.
Arteriosclerosis, thrombosis, and vascular biology - 1 Jul 2006
de Boer H C, Verseyden C, Ulfman L H, Zwaginga J J, Bot I, Biessen E A, Rabelink T J, van Zonneveld A J
Abstract excerpt
OBJECTIVE: Bone marrow-derived progenitor cells play a role in vascular regeneration. However, their homing to areas of vascular injury is poorly understood. One of the earliest responses to an injury is the activation of coagulation and platelets. In this study we assessed the role of hemostatic components in the recruitment of CD34+ cells to sites of injury. METHODS AND RESULTS: Using an ex vivo injury model,...
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