Article
Pigment-epithelium-derived factor (PEDF) inhibits angiotensin-II-induced vascular endothelial growth factor (VEGF) expression in MOLT-3 T cells through anti-oxidative properties.
Microvascular research - 1 May 2006
Yamagishi Sho-ichi, Matsui Takanori, Nakamura Kazuo, Yoshida Takafumi, Shimizu Kyoko, Takegami Yoshiaki, Shimizu Tadamichi, Inoue Hiroyoshi, Imaizumi Tsutomu
Abstract excerpt
Angiotensin II (Ang II), the dominant effector of the renin-angiotensin system, elicits numerous inflammatory-proliferative responses, thereby being involved in angiogenesis. T cells play an important role in angiogenesis as well by delivering vascular endothelial growth factor (VEGF) to inflammatory sites. Since we have previously shown that pigment-epithelium-derived factor (PEDF) blocks the Ang II signaling in...
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