Molecular characterization of an Enterobacter cloacae gene (romA) which pleiotropically inhibits the expression of Escherichia coli outer membrane proteins.

doi:10.1128/jb.172.7.4082-4089.1990

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Article

Molecular characterization of an Enterobacter cloacae gene (romA) which pleiotropically inhibits the expression of Escherichia coli outer membrane proteins.

Journal of bacteriology - 1 Jul 1990

Komatsu T, Ohta M, Kido N, Arakawa Y, Ito H, Mizuno T, Kato N

Abstract excerpt

The introduction of a newly cloned Enterobacter cloacae chromosomal gene romA, into Escherichia coli and E. cloacae resulted in enhancement of resistance to quinolones, beta-lactams, chloramphenicol, and tetracycline. The primary effect of romA on a multicopy vector in E. coli was almost complete inhibition of OmpF expression in the outer membrane. From the experiments with ompR and envZ mutants or with ompF-lacZ...

Topics

Amino Acid Sequence
Anti-Bacterial Agents
Bacterial Outer Membrane Proteins
Bacterial Proteins
Base Sequence
Chromosomes, Bacterial
Cloning, Molecular
Coliphages
Drug Resistance, Microbial
Enterobacter

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Enterobacteriaceae

Escherichia coli

Gene Expression Regulation, Bacterial

Genes, Bacterial

Genetic Vectors

Membrane Proteins

Microbial Sensitivity Tests

Molecular Sequence Data

Source

Open in PubMed Open full text

Identifiers

PMID: 2193928
DOI: 10.1128/jb.172.7.4082-4089.1990
PMCID: PMC213395

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-2193928-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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Molecular characterization of an Enterobacter cloacae gene (romA) which pleiotropically inhibits the expression of Escherichia coli outer membrane proteins.PMID 2193928Read ↗

Increased resistance to multiple drugs by introduction of the Enterobacter cloacae romA gene into OmpF porin-deficient mutants of Escherichia coli K-12.Semantic proximity Read ↗

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