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Article

Reactivation of developmentally expressed p63 isoforms predisposes to tumor development and progression.

Cancer research - 15 Apr 2006

Koster Maranke I, Lu Shi-Long, White Lisa D, Wang Xiao-Jing, Roop Dennis R

Abstract excerpt

Genes that are active during normal development are frequently reactivated during neoplastic transformation. We now report that developmentally expressed TAp63 isoforms are frequently reactivated in human squamous cell carcinomas. To determine the consequences of TAp63 reactivation, we induced TAp63alpha expression during chemically-induced skin carcinogenesis. Deregulated TAp63alpha expression dramatically...

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PMID: 16618715
DOI: 10.1158/0008-5472.CAN-06-0027

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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