Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Distinct function of P63 isoforms during embryonic skeletal development.

Gene - 1 May 2013

Lu Yaojuan, Abbassi Sam, Li Feifei, Ding Ming, Wu Guojun, Gu Junxia, Zheng Qiping

Abstract excerpt

P63 belongs to the P53 family of transcription factors. There are multiple P63 isoforms that play important functions both in cancer and development. The obvious limb defect in p63 null mice and in human skeletal syndromes with P63 mutations suggest its essential role in long bone development. However, how the different P63 isoforms function during long bone development is largely unknown. We have previously...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Bone and Bones
Share to Bone Development
Share to Chondrocytes

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Collagen Type II

Share to Collagen Type X

Share to Embryonic Development

Share to Osteogenesis

Share to SOX9 Transcription Factor

Source

Open in PubMed Open full text

Identifiers

PMID: 23481305
DOI: 10.1016/j.gene.2013.02.021
PMCID: PMC3628837

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Distinct function of P63 isoforms during embryonic skeletal development.PMID 23481305Read ↗

Mouse p63 variants and chondrogenesis.Semantic proximity Read ↗

Isoform-Specific Roles of Mutant p63 in Human DiseasesSemantic proximity Read ↗

Targeted p63 isoform switch corrects dominant mutations in AEC syndrome without disrupting epidermal homeostasisSemantic proximity Read ↗

p63 regulates multiple signalling pathways required for ectodermal organogenesis and differentiationSemantic proximity Read ↗

P63 gene mutations and human developmental syndromes.Semantic proximity Read ↗

Mutations in the p53 homolog p63: allele-specific developmental syndromes in humans.Semantic proximity Read ↗

Identification and functional characterization of two new transcriptional variants of the human p63 geneSemantic proximity Read ↗

p63, a story of mice and men.Semantic proximity Read ↗

p63-associated disorders.Semantic proximity Read ↗

Deletion of p63 exon 13 in mice reveals C-terminal isoform–specific functions in epithelial developmentSemantic proximity Read ↗

p63 in skin appendage development.Semantic proximity Read ↗

Contribution of p53, p63, and p73 to the developmental diseases and cancer.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.