Article
Assessing the role of APNH, a gene encoding for a human amiloride-sensitive Na+/H+ antiporter, on the interindividual variation in red cell Na+/Li+ countertransport.
Journal of the American Society of Nephrology : JASN - 1 Oct 1991
Dudley C R, Giuffra L A, Raine A E, Reeders S T
Abstract excerpt
The "reverse genetic" approach to essential hypertension is complicated by the fact that blood pressure is a heterogeneous, quantitative, complex trait. One strategy is to use "intermediate phenotypes" that are not only associated with hypertension but that also have a simple mode of inheritance,...
Topics
- Amiloride
- Biological Transport, Active
- Carrier Proteins
- Erythrocytes
- Female
- Genetic Linkage
- Humans
- Hypertension
- Lithium
- Male
- Pedigree
- Phenotype
- Polymorphism, Genetic
- Sodium
- Sodium-Hydrogen Exchangers