Article
Exclusion of the Na(+)-H+ antiporter as a candidate gene in human essential hypertension.
Hypertension (Dallas, Tex. : 1979) - 1 Jan 1991
Lifton R P, Hunt S C, Williams R R, Pouysségur J, Lalouel J M
Abstract excerpt
The primary abnormalities that contribute to the pathogenesis of human essential hypertension are unknown. The known genetic contribution to this disorder suggests the possible use of genetic linkage analysis to test whether specific candidate genes contribute to the pathogenesis of either essential hypertension or intermediate phenotypes. Among such phenotypes, elevated erythrocyte Na(+)-Li+ countertransport...
Topics
- Antiporters
- Carrier Proteins
- Chromosome Mapping
- Genes
- Genetic Linkage
- Genotype
- Humans
- Hypertension
- Pedigree
- Sodium-Hydrogen Exchangers