Article
Genome scans and gene expression microarrays converge to identify gene regulatory loci relevant in schizophrenia.
Human genetics - 1 Jun 2006
Vawter Marquis P, Atz Mary E, Rollins Brandi L, Cooper-Casey Kathleen M, Shao Ling, Byerley William F
Abstract excerpt
Multiple linkage regions have been reported in schizophrenia, and some appear to harbor susceptibility genes that are differentially expressed in postmortem brain tissue derived from unrelated individuals. We combined traditional genome-wide linkage analysis in a multiplex family with lymphocytic genome-wide expression analysis. A genome scan suggested linkage to a chromosome 4q marker (D4S1530, LOD 2.17, theta =...
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