Article
Mitochondrial genome distribution in histochemically cytochrome c oxidase-negative muscle fibres in patients with a mixture of deleted and wild type mitochondrial DNA.
Biochimica et biophysica acta - 21 Nov 1991
Collins S, Rudduck C, Marzuki S, Dennett X, Byrne E
Abstract excerpt
In situ hybridization studies were performed on a series of chronic progressive external ophthalmoplegia patients harbouring large mitochondrial DNA deletions, using intra- and extra-deletional probes. Clear differences in the distribution of wild type and deleted mitochondrial genomes were seen in both ragged-red and non-ragged red, cytochrome c oxidase-negative fibres, with an accumulation of deleted genomes in...
Topics
- Base Sequence
- Biopsy
- Chromosome Mapping
- DNA Probes
- DNA, Mitochondrial
- DNA, Single-Stranded
- Electron Transport Complex IV
- Histocytochemistry
- Humans
- Microtomy
- Mitochondria, Muscle