Article
Residual muscle cytochrome c oxidase activity accounts for submaximal exercise lactate threshold in chronic progressive external ophthalmoplegia.
Muscle & nerve - 1 Mar 1996
Siciliano G, Rossi B, Manca L, Angelini C, Tessa A, Vergani L, Martinuzzi A, Muratorio A
Abstract excerpt
The data from histological, biochemical, and mitochondrial DNA (mtDNA ) studies of muscle biopsies from 10 patients affected with chronic progressive external ophthalmoplegia (CPEO) were related to dynamic and metabolic parameters of incremental submaximal exercise. Maximum power output was reduced in all patients as compared to controls. Analysis of the venous lactate curve during exercise revealed a lactate...
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