Article
Mitochondrial DNA deletions in mitochondrial cytopathies: observations in 19 patients.
Neurology - 1 Nov 1991
Yamamoto M, Clemens P R, Engel A G
Abstract excerpt
Among 56 patients with mitochondrial myopathies or cytopathies, 19 had large-scale deletions of mitochondrial DNA (mtDNA). Consistent with previous observations, all 19 had progressive external ophthalmoplegia and 12 had complete or partial Kearns-Sayre syndrome. One of two patients in whom mitochondrial rather than whole muscle DNA was analyzed had multiple populations of deleted mtDNA (dmtDNA). In all patients,...
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