Article
RECQL4 Regulates p53 Function In Vivo During Skeletogenesis.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research - 1 Jun 2015
Lu Linchao, Harutyunyan Karine, Jin Weidong, Wu Jianhong, Yang Tao, Chen Yuqing, Joeng Kyu Sang, Bae Yangjin, Tao Jianning, Dawson Brian C, Jiang Ming-Ming, Lee Brendan, Wang Lisa L
Abstract excerpt
RECQ DNA helicases play critical roles in maintaining genomic stability, but their role in development has been less well studied. Rothmund-Thomson syndrome, RAPADILINO, and Baller-Gerold syndrome are rare genetic disorders caused by mutations in the RECQL4 gene. These patients have significant skeletal developmental abnormalities including radial ray, limb and craniofacial defects. To investigate the role of...
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