Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Krox20/EGR2 deficiency accelerates cell growth and differentiation in the monocytic lineage and decreases bone mass

18 Aug 2010

Abstract excerpt

Krox20/EGR2, one of the 4 early growth response genes, is a highly conserved transcription factor implicated in hindbrain development, peripheral nerve myelination, tumor suppression, and monocyte/macrophage cell fate determination. Here, we established a novel role for Krox20 in postnatal skeletal metabolism. Microcomputed tomographic analysis of 4- and 8-week-old mice revealed a low bone mass phenotype (LBM) in...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Bone and Dental Protein Studies
Share to Bone health and treatments
Share to Bone Metabolism and Diseases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 20716776
DOI: 10.1182/blood-2010-01-263830

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Krox20/EGR2 deficiency accelerates cell growth and differentiation in the monocytic lineage and decreases bone massPMID 20716776Read ↗

Defective bone formation in Krox-20 mutant mice.Semantic proximity Read ↗

Recql4 haploinsufficiency in mice leads to defects in osteoblast progenitors: Implications for low bone mass phenotype.Semantic proximity Read ↗

The DNA Helicase Recql4 Is Required for Normal Osteoblast Expansion and Osteosarcoma FormationSemantic proximity Read ↗

The Early Growth Response Gene Egr2 (Alias Krox20) Is a Novel Transcriptional Target of Transforming Growth Factor-β that Is Up-Regulated in Systemic Sclerosis and Mediates Profibrotic ResponsesSemantic proximity Read ↗

Increased trabecular bone formation in mice lacking the growth factor midkine.Semantic proximity Read ↗

Ezh2 mediates epigenetic regulation of osteoclastogenesis and bone remodeling in miceSemantic proximity Read ↗

The KDM4B–CCAR1–MED1 axis is a critical regulator of osteoclast differentiation and bone homeostasisSemantic proximity Read ↗

Precocious Chondrocyte Differentiation Disrupts Skeletal Growth in Kabuki Syndrome MiceSemantic proximity Read ↗

Mesenchymal expression of activated K-ras yields Noonan Syndrome-like bone defects that are rescued by mid-gestational MEK inhibitionSemantic proximity Read ↗

Precocious chondrocyte differentiation disrupts skeletal growth in Kabuki syndrome miceSemantic proximity Read ↗

Expression pattern of a Krox-20/Cre knock-in allele in the developing hindbrain, bones, and peripheral nervous system.Semantic proximity Read ↗

ERK1 and ERK2 Regulate Chondrocyte Terminal Differentiation During Endochondral Bone FormationSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.