Article
Assessing the influence of 5,10-methylenetetrahydrofolate reductase polymorphism on folate stability during long-term frozen storage, thawing, and repeated freeze/thawing of whole blood.
Clinica chimica acta; international journal of clinical chemistry - 14 Jun 2012
Fazili Zia, Sternberg Maya R, Pfeiffer Christine M
Abstract excerpt
BACKGROUND: Limited information is available on folate stability, particularly vitamer stability by 5,10-methylenetetrahydrofolate reductase (MTHFR) C677T genotype, during frozen storage, thawing, and repeated freeze/thawing (F/T) of whole blood (WB). METHODS: We assessed folate stability after storing undiluted WB for up to 30 mo at -70°C and measuring folate vitamers by LC-MS/MS at 6, 14, 20 and 30 mo in...
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