Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Mutations in the SLC2A9 gene cause hyperuricosuria and hyperuricemia in the dog.

PLoS genetics - 1 Nov 2008

Bannasch Danika, Safra Noa, Young Amy, Karmi Nili, Schaible R S, Ling G V

Abstract excerpt

Allantoin is the end product of purine catabolism in all mammals except humans, great apes, and one breed of dog, the Dalmatian. Humans and Dalmatian dogs produce uric acid during purine degradation, which leads to elevated levels of uric acid in blood and urine and can result in significant diseases in both species. The defect in Dalmatians results from inefficient transport of uric acid in both the liver and...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Chromosome Mapping
Share to Dog Diseases
Share to Dogs

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Glucose Transport Proteins, Facilitative

Share to Hyperuricemia

Share to Protein Isoforms

Share to Sequence Alignment

Share to Uric Acid

Source

Open in PubMed Open full text

Identifiers

PMID: 18989453
DOI: 10.1371/journal.pgen.1000246
PMCID: PMC2573870

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Mutations in the SLC2A9 gene cause hyperuricosuria and hyperuricemia in the dog.PMID 18989453Read ↗

Linkage analysis with an interbreed backcross maps Dalmatian hyperuricosuria to CFA03.Semantic proximity Read ↗

Exclusion of urate oxidase as a candidate gene for hyperuricosuria in the Dalmatian dog using an interbreed backcross.Semantic proximity Read ↗

Validation of a urine test and characterization of the putative genetic mutation for hyperuricosuria in Bulldogs and Black Russian Terriers.Semantic proximity Read ↗

Exclusion of galectin 9 as a candidate gene for hyperuricosuria in the Dalmatian dog.Semantic proximity Read ↗

Changing paradigms in diagnosis of inherited defects associated with urolithiasis.Semantic proximity Read ↗

Estimated frequency of the canine hyperuricosuria mutation in different dog breeds.Semantic proximity Read ↗

Inheritance of urinary calculi in the Dalmatian.Semantic proximity Read ↗

Canine models of copper toxicosis for understanding mammalian copper metabolism.Semantic proximity Read ↗

Cystinuria Associated with Different SLC7A9 Gene Variants in the Cat.Semantic proximity Read ↗

The Menkes and Wilson disease genes counteract in copper toxicosis in Labrador retrievers: a new canine model for copper-metabolism disorders.Semantic proximity Read ↗

Pathogenic GLUT9 mutations causing renal hypouricemia type 2 (RHUC2).Semantic proximity Read ↗

Renal Hypouricemia 1: Rare Disorder as Common Disease in Eastern Slovakia Roma PopulationSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.