Article
A TAP2 genotype associated with Alzheimer's disease in APOE4 carriers.
Neurobiology of aging - 1 Apr 2007
Bullido María J, Martínez-García Ana, Artiga María J, Aldudo Jesús, Sastre Isabel, Gil Pedro, Coria Francisco, Muñoz David G, Hachinski Vladimir, Frank Ana, Valdivieso Fernando
Abstract excerpt
Sporadic Alzheimer's disease (AD) appears to be the consequence of the interaction between combinations of genes and environmental factors. Binding with the transporter associated with antigen processing (TAP) is thought to be the main way in which herpes simplex virus type 1 (HSV-1) evades immune surveillance. Several TAP gene polymorphisms were examined and a TAP2 SNP (rs241448) associated with AD found in two...
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