Article
Dendritic cell differentiation and immune tolerance to insulin-related peptides in Igf2-deficient mice.
Journal of immunology (Baltimore, Md. : 1950) - 15 Apr 2006
Hansenne Isabelle, Renard-Charlet Chantal, Greimers Roland, Geenen Vincent
Abstract excerpt
There is some evidence that insulin-like growth factor 2 (IGF-2) may intervene in the control of T cell differentiation. To further study the immunoregulatory function of this growth factor, we analyzed the immune system of Igf2-/- mice. Phenotypically, some immunological parameters such as lymphoid organ morphology and cellularity were unaltered in Igf2-/- mice, but an increase of CD8+ cells and a decrease of...
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