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Article

oriP is essential for EBNA gene promoter activity in Epstein-Barr virus-immortalized lymphoblastoid cell lines

1 Sept 1996

Abstract excerpt

During Epstein-Barr virus latent infection of B lymphocytes in vitro, six viral nuclear antigens (EBNAs) are expressed from one of two promoters, Cp or Wp, whose activities are mutually exclusive. Upon infection, Wp is initially active, followed by a switch to Cp for the duration of latency. In this study, the region upstream of Cp was analyzed for the presence of cis elements involved in regulating the...

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Identifiers

PMID: 8709191
DOI: 10.1128/jvi.70.9.5758-5768.1996

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oriP is essential for EBNA gene promoter activity in Epstein-Barr virus-immortalized lymphoblastoid cell linesPMID 8709191Read ↗

B-cell lines immortalized with an Epstein-Barr virus mutant lacking the Cp EBNA2 enhancer are biased toward utilization of the oriP-proximal EBNA gene promoter Wp1.Semantic proximity Read ↗

Promoter switching in Epstein-Barr virus during the initial stages of infection of B lymphocytes.Semantic proximity Read ↗

Role for the Epstein-Barr virus nuclear antigen 2 in viral promoter switching during initial stages of infection.Semantic proximity Read ↗

The Epstein-Barr virus nuclear protein 1 promoter active in type I latency is autoregulatedSemantic proximity Read ↗

Determining the role of the Epstein-Barr virus Cp EBNA2-dependent enhancer during the establishment of latency by using mutant and wild-type viruses recovered from cottontop marmoset lymphoblastoid cell lines.Semantic proximity Read ↗

Identification and Characterization of CCAAT Enhancer-binding Protein (C/EBP) as a Transcriptional Activator for Epstein-Barr Virus Oncogene Latent Membrane Protein 1Semantic proximity Read ↗

Sequence requirements of the Epstein-Barr virus latent origin of DNA replicationSemantic proximity Read ↗

Lytic cycle gene regulation of Epstein-Barr virus.Semantic proximity Read ↗

Molecular genetic analysis of Epstein-Barr virus Cp promoter function.Semantic proximity Read ↗

Initiation of DNA replication within oriP is dispensable for stable replication of the latent Epstein-Barr virus chromosome after infection of established cell lines.Semantic proximity Read ↗

Cellular transcription factors recruit viral replication proteins to activate the Epstein–Barr virus origin of lytic DNA replication, oriLytSemantic proximity Read ↗

HCF1 and OCT2 Cooperate with EBNA1 To Enhance OriP-Dependent Transcription and Episome Maintenance of Latent Epstein-Barr VirusSemantic proximity Read ↗

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