Article
Wiskott-Aldrich syndrome protein is involved in alphaIIb beta3-mediated cell adhesion.
EMBO reports - 1 May 2006
Tsuboi Shigeru, Nonoyama Shigeaki, Ochs Hans D
Abstract excerpt
The Wiskott-Aldrich syndrome (WAS) is an X-chromosome-linked immunodeficiency disorder. The most common symptom seen in WAS patients is bleeding. One of the main causes of bleeding is defective platelet aggregation. The causative gene of WAS encodes WAS protein (WASP). Here, we show that WASP binds to the calcium- and integrin-binding protein (CIB) in platelets. CIB was originally identified as a protein binding...
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