Article
Bradyrhizobium japonicum senses iron through the status of haem to regulate iron homeostasis and metabolism.
Molecular microbiology - 1 Apr 2006
Yang Jianhua, Sangwan Indu, Lindemann Andrea, Hauser Felix, Hennecke Hauke, Fischer Hans-Martin, O'Brian Mark R
Abstract excerpt
The Irr protein from the bacterium Bradyrhizobium japonicum is expressed under iron limitation to mediate iron control of haem biosynthesis. The regulatory input to Irr is the status of haem and its precursors iron and protoporphyrin at the site of haem synthesis. Here, we show that Irr controls the expression of iron transport genes and many other iron-regulated genes not directly involved in haem synthesis. Irr...
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