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Article

Two heme binding sites are involved in the regulated degradation of the bacterial iron response regulator (Irr) protein.

The Journal of biological chemistry - 4 Mar 2005

Yang Jianhua, Ishimori Koichiro, O'Brian Mark R

Abstract excerpt

The iron response regulator (Irr) protein from Bradyrhizobium japonicum is a conditionally stable protein that degrades in response to cellular iron availability. This turnover is heme-dependent, and rapid degradation involves heme binding to a heme regulatory motif (HRM) of Irr. Here, we show th...

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PMID: 15613477
DOI: 10.1074/jbc.M411664200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-15613477-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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