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Article

Repression of the Insulin-Like Growth Factor II Gene by the Wilms Tumor Suppressor WT1

31 Jul 1992

Abstract excerpt

The Wilms tumor suppressor gene wt1 encodes a zinc finger DNA binding protein, WT1, that functions as a transcriptional repressor. The fetal mitogen insulin-like growth factor II (IGF-II) is overexpressed in Wilms tumors and may have autocrine effects in tumor progression. The major fetal IGF-II promoter was defined in transient transfection assays as a region spanning from nucleotides -295 to +135, relative to...

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PMID: 1323141
DOI: 10.1126/science.1323141

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