Article
Quadruple mutations in dihydrofolate reductase of Plasmodium falciparum isolates from Car Nicobar Island, India.
Antimicrobial agents and chemotherapy - 1 Apr 2006
Ahmed Anwar, Das Manoj K, Dev Vas, Saifi Muheet A, Wajihullah, Sharma Yagya D
Abstract excerpt
Quadruple mutations in the Plasmodium falciparum dihydrofolate reductase (PFDHFR) enzyme give rise to the highest level of pyrimethamine resistance leading to treatment failures. We describe here the presence of these quadruple mutations in a majority of P. falciparum isolates from Car Nicobar (Andaman and Nicobar) Island, India. Isolates from the mainland, however, continue to show a prevalence of double PFDHFR...
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