Article
High chloroquine treatment failure rates and predominance of mutant genotypes associated with chloroquine and antifolate resistance among falciparum malaria patients from the island of Car Nicobar, India.
The Journal of antimicrobial chemotherapy - 1 Jun 2010
Das Manoj K, Lumb Vanshika, Mittra Pooja, Singh Shiv S, Dash Aditya P, Sharma Yagya D
Abstract excerpt
OBJECTIVES: An in vivo chloroquine efficacy study was undertaken on the island of Car Nicobar because a temporal rise in the Plasmodium falciparum parasite population containing mutations in the chloroquine resistance transporter (PfCRT) protein has been reported there. METHODS: A WHO protocol with a 28 day follow-up schedule was used for chloroquine efficacy studies. Finger-prick blood from P. falciparum malaria...
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