Article
Noninvasive genotyping of 9 Y-chromosome specific STR loci using circulatory fetal DNA in maternal plasma by multiplex PCR.
Prenatal diagnosis - 1 Apr 2006
Deng ZhiHui, Wu GuoGuang, Li Qian, Zhang Xuan, Liang YanLian, Li DaCheng, Gao SuQing, Lan YuXiao
Abstract excerpt
BACKGROUND: Human Y-Chromosome specific STR (Y-STR) has now become a useful loci in casework. However, noninvasive genotyping of multiple Y-STR loci and its application in prenatal genetic diagnosis haven't been reported. The purpose of this study is to develop a Y-STR multiplex PCR amplification system that is suitable for the amplification of short-sized templates of circulatory male fetal DNA and use the...
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