Article
The critical roles of serum/glucocorticoid-regulated kinase 3 (SGK3) in the hair follicle morphogenesis and homeostasis: the allelic difference provides novel insights into hair follicle biology.
The American journal of pathology - 1 Apr 2006
Okada Taro, Ishii Yoshiyuki, Masujin Kentaro, Yasoshima Akira, Matsuda Junichiro, Ogura Atsuo, Nakayama Hiroyuki, Kunieda Tetsuo, Doi Kunio
Abstract excerpt
Mutation in the serum/glucocorticoid regulated kinase 3 (Sgk3, also known as Sgkl or Cisk) gene causes both defective hair follicle development and altered hair cycle in mice. We examined Sgk3-mutant YPC mice (YPC-Sgk3(ypc)/Sgk3(ypc)) and found expression of SGK3 protein with altered function. In the hair follicles of YPC mice, the aberrant differentiation and poor proliferation of hair matrix keratinocytes...
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