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Article

Soluble misfolded subfractions of mutant superoxide dismutase-1s are enriched in spinal cords throughout life in murine ALS models.

Proceedings of the National Academy of Sciences of the United States of America - 28 Aug 2007

Zetterström Per, Stewart Heather G, Bergemalm Daniel, Jonsson P Andreas, Graffmo Karin S, Andersen Peter M, Brännström Thomas, Oliveberg Mikael, Marklund Stefan L

Abstract excerpt

Mutants of superoxide dismutase-1 (SOD1) cause ALS by an unidentified cytotoxic mechanism. We have previously shown that the stable SOD1 mutants D90A and G93A are abundant and show the highest levels in liver and kidney in transgenic murine ALS models, whereas the unstable G85R and G127X mutants are scarce but enriched in the CNS. These data indicated that minute amounts of misfolded SOD1 enriched in the motor...

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Identifiers

PMID: 17715066
DOI: 10.1073/pnas.0700477104
PMCID: PMC1955813

Genes

SOD1

Variants

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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