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Article

A promoter haplotype of the interleukin-18 gene is associated with juvenile idiopathic arthritis in the Japanese population.

Arthritis research & therapy - 1 Jan 2006

Sugiura Tomoko, Maeno Nobuaki, Kawaguchi Yasushi, Takei Syuji, Imanaka Hiroyuki, Kawano Yoshifumi, Terajima-Ichida Hisae, Hara Masako, Kamatani Naoyuki

Abstract excerpt

Recently, we reported that genetic polymorphisms within the human IL18 gene were associated with disease susceptibility to adult-onset Still's disease (AOSD), which is characterized by extraordinarily high serum levels of IL-18. Because high serum IL-18 induction has also been observed in the systemic type of juvenile idiopathic arthritis (JIA), we investigated whether similar genetic skewing is present in this...

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PMID: 16563174
DOI: 10.1186/ar1930
PMCID: PMC1526617

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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