Article
Coinheritance of Gilbert syndrome-associated UGT1A1 mutation increases gallstone risk in cystic fibrosis.
Hepatology (Baltimore, Md.) - 1 Apr 2006
Wasmuth Hermann E, Keppeler Hildegard, Herrmann Ulrike, Schirin-Sokhan Ramin, Barker Michael, Lammert Frank
Abstract excerpt
The prevalence of "black" pigment gallstones is increased in patients with cystic fibrosis (CF). Bile acid malabsorption with augmented bilirubin uptake from the intestine and the development of "hyperbilirubinbilia" have been proposed as key factors in gallstone formation in CF patients. We have now tested the hypothesis that the coinheritance of the common UGT1A1 promoter mutation associated with Gilbert...
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