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Article

GATA6 Regulates Aortic Valve Remodeling, and Its Haploinsufficiency Leads to Right-Left Type Bicuspid Aortic Valve.

Circulation - 4 Sept 2018

Gharibeh Lara, Komati Hiba, Bossé Yohan, Boodhwani Munir, Heydarpour Mahyar, Fortier Megan, Hassanzadeh Romina, Ngu Janet, Mathieu Patrick, Body Simon, Nemer Mona

Abstract excerpt

BACKGROUND: Bicuspid aortic valve (BAV), the most common congenital heart defect affecting 1% to 2% of the population, is a major risk factor for premature aortic valve disease and accounts for the majority of valve replacement. The genetic basis and mechanisms of BAV etiology and pathogenesis remain largely undefined. METHODS: Cardiac structure and function was assessed in mice lacking a Gata6 allele. Human...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 29567669
DOI: 10.1161/CIRCULATIONAHA.117.029506
PMCID: PMC6151169

Genes

GATA6

Provenance

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