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Article

Mechanistic differences in actin bundling activity of two mammalian formins, FRL1 and mDia2.

The Journal of biological chemistry - 19 May 2006

Harris Elizabeth S, Rouiller Isabelle, Hanein Dorit, Higgs Henry N

Abstract excerpt

Formin proteins are regulators of actin dynamics, mediating assembly of unbranched actin filaments. These multidomain proteins are defined by the presence of a Formin Homology 2 (FH2) domain. Previous work has shown that FH2 domains bind to filament barbed ends and move processively at the barbed end as the filament elongates. Here we report that two FH2 domains, from mammalian FRL1 and mDia2, also bundle...

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Identifiers

PMID: 16556604
DOI: 10.1074/jbc.M510923200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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