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Ewing Sarcoma Family of Tumors

1 Jul 2005

Abstract excerpt

The Ewing sarcoma family of tumors (ESFT) comprises morphologically heterogeneous tumors that are characterized by nonrandom chromosomal translocations involving the EWS gene and one of several members of the ETS family of transcription factors. The translocation t(11;22)(q24;q12) is the most common and leads to the formation of the EWS-FLI1 fusion protein, which contributes to ESFT pathogenesis by modulating the...

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PMID: 16096383
DOI: 10.1097/01.pap.0000175114.55541.52

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