Article
Epithelial growth factor receptor status in primary and recurrent ovarian cancer.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc - 1 Apr 2006
Stadlmann Sylvia, Gueth Uwe, Reiser Ulrich, Diener Pierre-Andre, Zeimet Alain Gustave, Wight Edward, Mirlacher Martina, Sauter Guido, Mihatsch Michael J, Singer Gad
Abstract excerpt
Success of epidermal growth factor receptor (EGFR) targeting agents in different cancer types is related to EGFR gene mutations and/or copy number gains. We investigated the EGFR gene status and protein expression by DNA mutational analysis, fluorescence in situ hybridization (FISH), and immunohistochemistry in tumor tissues from 80 patients with primary and corresponding recurrent ovarian serous carcinomas. The...
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