c-myc gene-induced alterations in protein kinase C expression: a possible mechanism facilitating myc-ras gene complementation.

Article

c-myc gene-induced alterations in protein kinase C expression: a possible mechanism facilitating myc-ras gene complementation.

Cancer research - 15 Oct 1991

Barr L F, Mabry M, Nelkin B D, Tyler G, May W S, Baylin S B

Abstract excerpt

The mechanism(s) by which the c-myc nuclear protein and the membrane-associated ras protein interact to mediate phenotypic changes is unknown. We now find that c-mcy gene expression is associated with alterations in the principal signal transduction pathway through which the ras protein is though...

Topics

Carcinoma, Small Cell
Gene Expression Regulation, Neoplastic
Genes, myc
Genes, ras
Isoenzymes
Molecular Weight
Phenotype
Protein Kinase C
RNA, Messenger
Transfection
Tumor Cells, Cultured

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