Article
Ab-induced ectodomain shedding mediates hepatocyte growth factor receptor down-regulation and hampers biological activity.
Proceedings of the National Academy of Sciences of the United States of America - 28 Mar 2006
Petrelli Annalisa, Circosta Paola, Granziero Luisa, Mazzone Massimiliano, Pisacane Alberto, Fenoglio Silvia, Comoglio Paolo M, Giordano Silvia
Abstract excerpt
Targeting tyrosine kinase receptors (RTKs) with specific Abs is a promising therapeutic approach for cancer treatment, although the molecular mechanism(s) responsible for the Abs' biological activity are not completely known. We targeted the transmembrane RTK for hepatocyte growth factor (HGF) with a monoclonal Ab (DN30). In vitro, chronic treatment of carcinoma cell lines resulted in impairment of HGF-induced...
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