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Article

Therapeutic targeting of human hepatocyte growth factor with a single neutralizing monoclonal antibody reduces lung tumorigenesis.

Molecular cancer therapeutics - 1 Jul 2008

Stabile Laura P, Rothstein Mary E, Keohavong Phouthone, Jin Jide, Yin Jinling, Land Stephanie R, Dacic Sanja, Luong The Minh, Kim K Jin, Dulak Austin M, Siegfried Jill M

Abstract excerpt

The hepatocyte growth factor (HGF)/c-Met signaling pathway is involved in lung tumor growth and progression, and agents that target this pathway have clinical potential for lung cancer treatment. L2G7, a single potent anti-human HGF neutralizing monoclonal antibody, showed profound inhibition of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 18645002
DOI: 10.1158/1535-7163.MCT-07-2169
PMCID: PMC2556508

Genes

HGF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-18645002-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

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Therapeutic targeting of human hepatocyte growth factor with a single neutralizing monoclonal antibody reduces lung tumorigenesis.PMID 18645002Read ↗

A selective small molecule inhibitor of c-Met, PHA-665752, reverses lung premalignancy induced by mutant K-rasSemantic proximity Read ↗

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Single-Agent and Combination Therapeutic Strategies to Inhibit Hepatocyte Growth Factor/MET Signaling in CancerSemantic proximity Read ↗

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