Article
A study of the relationships between KLF2 polymorphisms and body weight control in a French population.
BMC medical genetics - 16 Mar 2006
Meirhaeghe Aline, Cottel Dominique, Amouyel Philippe
Abstract excerpt
BACKGROUND: Factors governing adipose tissue differentiation play a major role in obesity development in humans. The Krüppel-like zinc finger transcription factor KLF2/Lung KLF (LKLF) is a negative regulator of adipocyte differentiation. In this study, we sequenced the human KLF2 gene and several common polymorphisms were found, among them the Pro104Leu and 3'UTR 1239C>A polymorphisms. METHODS: To evaluate the...
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