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Article

Decreased peroxisome proliferator activated receptor alpha is associated with bile duct injury in cystic fibrosis transmembrane conductance regulator-/- mice.

Journal of pediatric gastroenterology and nutrition - 1 Mar 2006

Pall Harpreet, Zaman Munir M, Andersson Charlotte, Freedman Steven D

Abstract excerpt

BACKGROUND: Primary sclerosing cholangitis (PSC) is associated with mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene. As proof of concept that CFTR dysfunction plays a role in PSC, induction of colitis in cftr mice results in bile duct injury that can be prevented...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 16540796
DOI: 10.1097/01.mpg.0000189368.37535.42

Genes

CFTR
TNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-16540796-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 9 closest

Decreased peroxisome proliferator activated receptor alpha is associated with bile duct injury in cystic fibrosis transmembrane conductance regulator-/- mice.PMID 16540796Read ↗

Induction of colitis in cftr-/- mice results in bile duct injury.Semantic proximity Read ↗

SHP-dependent and -independent induction of peroxisome proliferator-activated receptor-γ by the bile acid sensor farnesoid X receptor counter-regulates the pro-inflammatory phenotype of liver myofibroblasts.Semantic proximity Read ↗

Regulation of peroxisome proliferator-activated receptor-gamma in liver fibrosis.Semantic proximity Read ↗

Editor's Highlight: Clofibrate Decreases Bile Acids in Livers of Male Mice by Increasing Biliary Bile Acid Excretion in a PPARα-Dependent Manner.Semantic proximity Read ↗

PPARα is down-regulated following liver transplantation in mice.Semantic proximity Read ↗

Tumor necrosis factor-alpha inhibits peroxisome proliferator-activated receptor gamma activity at a posttranslational level in hepatic stellate cells.Semantic proximity Read ↗

Ineffective correction of PPARγ signaling in cystic fibrosis airway epithelial cells undergoing repair.Semantic proximity Read ↗

Peroxisome proliferator-activated receptor gamma induces a phenotypic switch from activated to quiescent hepatic stellate cells.Semantic proximity Read ↗

PPARdelta status and Apc-mediated tumourigenesis in the mouse intestine.Semantic proximity Read ↗

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