Article
Family-based association analysis validates chromosome 3p21 as a putative nasopharyngeal carcinoma susceptibility locus.
Genetics in medicine : official journal of the American College of Medical Genetics - 1 Mar 2006
Zeng Zhaoyang, Zhou Yanhong, Zhang Wenling, Li Xiaoling, Xiong Wei, Liu Huaying, Fan Songqing, Qian Jun, Wang Lili, Li Zheng, Shen Shourong, Li Guiyuan
Abstract excerpt
PURPOSE: Nasopharyngeal carcinoma (NPC) poses one of the serious health problems in southern Chinese, with an incidence rate ranging from 15 to 50/100,000. In our previously linkage analysis, a locus on 3p21 was identified to link to NPC. In this study, family-based association analysis was performed to test the transmission disequilibrium of chromosome 3p in 18 high-risk nasopharyngeal carcinoma families of...
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