Article
Haplotype of gene Nedd4 binding protein 2 associated with sporadic nasopharyngeal carcinoma in the Southern Chinese population.
Journal of translational medicine - 13 Jul 2007
Zheng Mei-Zhen, Qin Hai-De, Yu Xing-Juan, Zhang Ru-Hua, Chen Li-Zhen, Feng Qi-Sheng, Zeng Yi-Xin
Abstract excerpt
BACKGROUND: Bcl-3 as an oncoprotein is overexpressed in nasopharyngeal carcinoma (NPC). Nedd4 binding protein 2 (N4BP2), which is located in the NPC susceptibility locus, is a Bcl-3 binding protein. This study is aimed to explore the association between N4BP2 genetic polymorphism and the risk of NPC. METHODS: We performed a hospital-based case-control study, including 531 sporadic NPC and 480 cancer-free control...
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