Article
Identification of the cytochrome P450 monooxygenase that bridges the clavine and ergoline alkaloid pathways.
Chembiochem : a European journal of chemical biology - 1 Apr 2006
Haarmann Thomas, Ortel Ingo, Tudzynski Paul, Keller Ullrich
Abstract excerpt
Clavines and D-lysergic acid-derived alkaloid amides and alkaloid peptides are two different families of compounds that have the indole-derived tetracyclic metergoline ring system in common. Previous work has shown that D-lysergic acid is biosynthetically derived from clavine alkaloids. Recent cloning and analysis of the ergot alkaloid biosynthesis gene cluster from the D-lysergic acid peptide...
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