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Article

Comparison of ergot alkaloid biosynthesis gene clusters in Claviceps species indicates loss of late pathway steps in evolution of C. fusiformis.

Applied and environmental microbiology - 1 Nov 2007

Lorenz Nicole, Wilson Ella V, Machado Caroline, Schardl Christopher L, Tudzynski Paul

Abstract excerpt

The grass parasites Claviceps purpurea and Claviceps fusiformis produce ergot alkaloids (EA) in planta and in submerged culture. Whereas EA synthesis (EAS) in C. purpurea proceeds via clavine intermediates to lysergic acid and the complex ergopeptines, C. fusiformis produces only agroclavine and elymoclavine. In C. purpurea the EAS gene (EAS) cluster includes dmaW (encoding the first pathway step), cloA...

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PMID: 17720822
DOI: 10.1128/AEM.01040-07
PMCID: PMC2168186

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