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Article

Familial clustering of site-specific cancer risks associated with BRCA1 and BRCA2 mutations in the Ashkenazi Jewish population.

Proceedings of the National Academy of Sciences of the United States of America - 7 Mar 2006

Simchoni Sharon, Friedman Eitan, Kaufman Bella, Gershoni-Baruch Ruth, Orr-Urtreger Avi, Kedar-Barnes Inbal, Shiri-Sverdlov Ronit, Dagan Efrat, Tsabari Sigal, Shohat Mordechai, Catane Raphael, King Mary-Claire, Lahad Amnon, Levy-Lahad Ephrat

Abstract excerpt

Inherited mutations in BRCA1 and BRCA2 lead to significantly increased risks of breast and ovarian cancer. We used epidemiologic methods to evaluate the relative risks of breast cancer vs. ovarian cancer among women of Ashkenazi Jewish ancestry with inherited mutations in BRCA1 or BRCA2. The cancer of a family's index case (i.e., breast cancer vs. ovarian cancer) was significantly associated with site-specific...

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Source

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Identifiers

PMID: 16537453
DOI: 10.1073/pnas.0511301103
PMCID: PMC1450152

Genes

BRCA1
BRCA2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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