Article
Expression profiles and single-nucleotide polymorphism analysis of human HANP1/H1T2 encoding a histone H1-like protein.
International journal of andrology - 1 Apr 2006
Tanaka Hiromitsu, Matsuoka Yasuhiro, Onishi Masayoshi, Kitamura Kouichi, Miyagawa Yasushi, Nishimura Hiromi, Tsujimura Akira, Okuyama Akihiko, Nishimune Yoshitake
Abstract excerpt
Recently we cloned the Hanp1 cDNA that encodes a histone H1-like haploid germ cell-specific nuclear protein in the mouse. Homozygous Hanp1 mutant male mice were infertile, while females were fertile. Although a substantial number of sperm were recovered from the epididymis, their shape and function were abnormal. Hanp1 protein is essential for nuclear formation in functional spermatozoa, and is specifically...
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