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Isolation and functional analysis of human HMBOX1, a homeobox containing protein with transcriptional repressor activity

1 Jan 2006

Abstract excerpt

We have identified and isolated a novel human gene, HMBOX1 (homeobox containing 1) from a pancreatic cDNA library. Human HMBOX1 is widely expressed in 18 tissues, and it is highly expressed in pancreas. According to the genome database, HMBOX1 is located at the boundary of 8p12.3 and 8p21.1. HMBOX1 proteins are highly conserved in human, mouse, rat, chicken and Xenopus laevis. A phylogenetic tree shows that...

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PMID: 16825764
DOI: 10.1159/000093328

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