Genome scan for loci predisposing to anxiety disorders using a novel multivariate approach: strong evidence for a chromosome 4 risk locus.

doi:10.1086/501072

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Article

Genome scan for loci predisposing to anxiety disorders using a novel multivariate approach: strong evidence for a chromosome 4 risk locus.

American journal of human genetics - 1 Apr 2006

Kaabi Belhassen, Gelernter Joel, Woods Scott W, Goddard Andrew, Page Grier P, Elston Robert C

Abstract excerpt

We conducted a 10-centimorgan linkage autosomal genome scan in a set of 19 extended American pedigrees (219 subjects) ascertained through probands with panic disorder. Several anxiety disorders--including social phobia, agoraphobia, and simple phobia--in addition to panic disorder segregate in these families. In previous studies of this sample, linkage analyses were based separately on each of the individual...

Topics

Anxiety
Chromosome Mapping
Chromosomes, Human, Pair 4
Genetic Linkage
Genetic Predisposition to Disease
Humans
Multivariate Analysis
Risk Factors

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PMID: 16532386
DOI: 10.1086/501072
PMCID: PMC1424685

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