Article
Targeted genome screen of panic disorder and anxiety disorder proneness using homology to murine QTL regions.
American journal of medical genetics - 8 Mar 2001
Smoller J W, Acierno J S, Rosenbaum J F, Biederman J, Pollack M H, Meminger S, Pava J A, Chadwick L H, White C, Bulzacchelli M, Slaugenhaupt S A
Abstract excerpt
Family and twin studies have indicated that genes influence susceptibility to panic and phobic anxiety disorders, but the location of the genes involved remains unknown. Animal models can simplify gene-mapping efforts by overcoming problems that complicate human pedigree studies including genetic heterogeneity and high phenocopy rates. Homology between rodent and human genomes can be exploited to map human genes...
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