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Control of mitochondrial biogenesis during myogenesis

10 Mar 2006

Abstract excerpt

We used expression and reporter gene analysis to understand how changes in transcription factors impinge on mitochondrial gene expression during myogenesis of cultured murine myoblasts (C2C12 and Sol8). The mRNA levels for nuclear respiratory factor-1 (NRF-1) and NRF-2alpha increased 60% by the third day of myogenesis, whereas NRF-1 and NRF-2 reporter gene activity increased by fivefold over the same period....

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PMID: 16531567
DOI: 10.1152/ajpcell.00463.2005

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